Memory formation in the absence of experience.

Vetere G, Tran LM, Moberg S, Steadman PE, Restivo L, Morrison FG, Ressler KJ, Josselyn SA, Frankland PW.

Nat Neurosci (2019) 933-940.

Abstract

Memory is coded by patterns of neural activity in distinct circuits. Therefore, it should be possible to reverse engineer a memory by artificially creating these patterns of activity in the absence of a sensory experience. In olfactory conditioning, an odor conditioned stimulus (CS) is paired with an unconditioned stimulus (US ; for example, a footshock), and the resulting CS-US association guides future behavior. Here we replaced the odor CS with optogenetic stimulation of a specific olfactory glomerulus and the US with optogenetic stimulation of distinct inputs into the ventral tegmental area that mediate either aversion or reward. In doing so, we created a fully artificial memory in mice. Similarly to a natural memory, this artificial memory depended on CS-US contingency during training, and the conditioned response was specific to the CS and reflected the US valence. Moreover, both real and implanted memories engaged overlapping brain circuits and depended on basolateral amygdala activity for expression.

Haut de page



À lire aussi...

Notre recherche

Le champ de recherche du laboratoire Plasticité du Cerveau est l’étude des mécanismes moléculaires, cellulaires, anatomiques et comportementaux de la (...) 

> Lire la suite...

Drosophila Clock is required in brain pacemaker neurons to prevent premature locomotor aging independently of its circadian function

Vaccaro A., Issa A.-R., Seugnet L., Birman S.* & Klarsfeld A.* PLOS Genetics (2017). 13(1):e1006507. Abstract Circadian clocks control many (...) 

> Lire la suite...

 


Informations Pratiques

Directeur d’unité
Thomas Preat
thomas.preat (arobase) espci.fr

Gestionnaire
Tu-Khanh Nguyen
tu-khanh.nguyen (arobase) espci.fr

Tél : +33 (0) 1 40 79 43 02

Nous contacter