Editorial

About the laboratory

The research field of the Brain Plasticity laboratory is the study of the molecular, cellular, anatomical and behavioral mechanisms of neuroplasticity. This theme is addressed by an integrated multidisciplinary approach, combining genetics, molecular and cellular biology, neural network studies, brain imaging, physiology and behavior.

Our laboratory brings together researchers interested in understanding the functioning of the brain at different scales, in order to develop collaborations and synergies. Complementary biological models are studied, namely the isolated nerve cell (Zsolt Lenkeï’s team), the brain of the Drosophila (Thomas Preat’s team and Serge Birman’s team), the brain of mammals (Karim Benchenane’s team and Sophie Pezet’s team), and the human brain (François Vialatte’s team).

The unique situation of the Brain Plasticity laboratory, within ESPCI Paris, allows us to develop unusual and fruitful bridges between neurobiology and physics.

In the light and continuity of the study of basic mechanisms of neuroplasticity, our projects include, concretely or potentially, applications to human cerebral pathology. We are interested in certain neurological or psychiatric conditions such as the effects of cannabinoids on memory or major psychiatric illnesses (depression, schizophrenia) (Zsolt Lenkei’s team and Karim Benchenane’s team), understanding neuronal mechanisms involved in sleep physiology (Karim Benchenane’s team), neuropathic pain (Sophie Pezet’s team) or studying Genetic models in Drosophila, molecular mechanisms involved in Parkinson’s disease (Serge Birman’s team), and Alzheimer’s disease (Thomas Preat’s team and François Vialatte’s team). The applied nature of this work, particularly in physics and neuropathology, suggests that they may lead to valuations at the industrial level (brain-computer interface, caracterisation of molecules).



News

Karim BENCHENANE : ERC Consolidator Grant 2016

Karim BENCHENANE, Head of the Memory, Oscillations and Brain States team is the recipient of an ERC Consolidator Grant that supports ambitious projects. He is encouraged for his work on the manipulation of memories of aversive experiences during sleep via a brain-machine interface (MNEMOSYNE Project).

Sophie PEZET : Head of the emerging team PNA

Sophie PEZET, Lecturer at ESPCI Paris, has headed the PNA (Pain and Neural Adaptation) team since 1 January 2017. Its current members are Miguel THIBAUT, ATER at ESPCI; Line RAHAL, in joint thesis with the Langevin Institute and Julien CLARON, on a Master 2 internship. Sophie PEZET becomes the 6th head of the Brain Plasticity Unit. Her...

Thomas PREAT: ERC Advanced Grant 2016

Thomas PREAT, Head of the Genes and Dynamics of Memory Systems team, is the recipient of an ERC Advanced Grant. This attribution confirms his position as a leader in the field of memory neurobiology. His EnergyMemo project focuses on the integrated physiological study in drosophila of the interplay between energy metabolism and long-term...

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Recent publications

Cannabinoid receptor activation in the juvenile rat brain results in rapid biomechanical alterations: Neurovascular mechanism as a putative confounding factor

Chatelin S., Humbert-Claude M., Garteiser P., Ricobaraza A., Vilgrain V., Van
Beers B.E., Sinkus R., *Lenkei Z.*

Journal of Cerebral Blood Flow & Metabolism (2016) 36(5):954-64.

Abstract

We... (...)


A psychoengineering paradigm for the neurocognitive mechanisms of biofeedback and neurofeedback

Gaume A., Vialatte A., Mora-Sánchez A., Ramdani C., Vialatte F.B.

Neuroscience & Biobehavioral Reviews (2016) 68:891-910.

Abstract

We believe that the missing keystone to design effective and ... (...)


Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory

Turrel O., Lampin-Saint-Amaux A., Preat T., Goguel V.

Journal of Neuroscience (2016) 36(37):9535-46.

Abstract

Neprilysins are type II metalloproteinases known to degrade and inactivate a number of ... (...)


Drosophila Clock is required in brain pacemaker neurons to prevent premature locomotor aging independently of its circadian function

Vaccaro A., Issa A.-R., Seugnet L., Birman S.* & Klarsfeld A.*

PLOS Genetics (2017). 13(1):e1006507.

Abstract

Circadian clocks control many self-sustained rhythms in physiology and behavior... (...)


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Practical information

Unit Director
Thomas Preat
thomas.preat (arobase) espci.fr

Administrator chief
Stéphanie Ledoux
stephanie.ledoux (arobase) espci.fr

Administrator
Tu-Khanh Nguyen
tu-khanh.nguyen (arobase) espci.fr

Phone : +33 (0) 1 40 79 43 02

To contact us