Plasticité du Cerveau

Memory formation in the absence of experience.

Tu Khanh NGUYEN — 2017-04-03T12:11:38Z

Nat Neurosci (2019) 933-940.
Vetere G, Tran LM, Moberg S, Steadman PE, Restivo L, Morrison FG, Ressler KJ, Josselyn SA, Frankland PW.
Abstract
Memory is coded by patterns of neural activity in distinct circuits. Therefore, it should be possible to reverse engineer a memory by artificially creating these patterns of activity in the absence of a sensory experience. In olfactory conditioning, an odor conditioned stimulus (CS) is paired with an unconditioned stimulus (US ; for example, a (…)

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Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety

Faure Philippe — 2021-11-24T17:07:23Z

Neuron (2021) Aug 18 ;109(16):2604-2615.
Claire Nguyen, Sarah Mondoloni , Tinaïg Le Borgne , Ines Centeno , Maxime Come, Joachim Jehl, Clément Solié, Lauren M Reynolds, Romain Durand-de Cuttoli, Stefania Tolu, Sébastien Valverde, Steve Didienne, Bernadette Hannesse , Jean-François Fiancette, Stéphanie Pons , Uwe Maskos, Véronique Deroche-Gamonet , Deniz Dalkara, Jean-Pierre Hardelin, Alexandre Mourot, Fabio Marti, Philippe Faure
Abstract
Nicotine stimulates dopamine (DA) neurons (…)

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An inhibitory hippocampal–thalamic pathway modulates remote memory retrieval

Faure Philippe — 2021-11-24T17:26:15Z

Nat Neurosci 2021 May ;24(5):685-693.
Gisella Vetere, Frances Xia, Adam I Ramsaran, Lina M Tran, Sheena A Josselyn, Paul W Frankland.
Abstract
Memories are supported by distributed hippocampal-thalamic-cortical networks, but the brain regions that contribute to network activity may vary with memory age. This process of reorganization is referred to as systems consolidation, and previous studies have examined the relationship between the activation of different hippocampal, thalamic, (…)

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Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice

Faure Philippe — 2021-11-29T17:45:28Z

Nature Communications volume 12, Article number : 6945 (2021)
Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne K. Duranté, Damien Lemoine, Raphaël Brito, Tarek Ahmed Yahia, Sarah Mondoloni, Steve Didienne, Elise Bousseyrol, Bernadette Hannesse, Lauren M. Reynolds, Nicolas Torquet, Deniz Dalkara, Fabio Marti, Alexandre Mourot, Jérémie Naudé & Philippe Faure
Abstract
Long-term exposure to nicotine alters brain circuits and induces profound changes in (…)

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Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory.

Faure Philippe — 2021-12-02T08:58:44Z

Cell report 2021 24 ;36(8):109620
de Tredern E, Rabah Y, Pasquer L, Minatchy J, Plaçais PY, Preat T.
Abstract
Brain function relies almost solely on glucose as an energy substrate. The main model of brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes to fuel the energy-demanding neuronal activity underlying plasticity and memory. Whether direct neuronal glucose uptake is required for memory formation remains elusive. We uncover, in Drosophila, (…)

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Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation

Faure Philippe — 2021-12-10T15:53:41Z

Nature Communications 2021 volume 12-2605
Sophie Bagur, Julie M. Lefort, Marie M. Lacroix, Gaëtan de Lavilléon, Cyril Herry, Mathilde Chouvaeff, Clara Billand, Hélène Geoffroy & Karim Benchenane
Abstract
Brain–body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm to the (…)

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Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation

Faure Philippe — 2022-03-07T08:14:37Z

Nature Metabolism 2022 4, pages 213–224 (2022)
Bryon Silva, Olivier L. Mantha, Johann Schor, Alberto Pascual, Pierre-Yves Plaçais, Alice Pavlowsky & Thomas Preat
Abstract
During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity relies on metabolic adaptation remains unclear. Here we show (…)

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Dopaminergic and prefrontal dynamics co-determine mouse decisions in a spatial gambling task

Faure Philippe — 2023-05-22T08:37:10Z

Cell Report 2023
Elise Bousseyrol, Steve Didienne, Samir Takillah, Clement Solié, Maxime Come, Tarek Ahmed Yahia, Sarah Mondoloni, Eléonore Vicq, Ludovic Tricoire, Alexandre Mourot, Jérémie Naudé, Philippe Faure
Abstract
The neural mechanisms by which animals initiate goal-directed actions, choose between options, or explore opportunities remain unknown. Here, we develop a spatial gambling task in which mice, to obtain intracranial self-stimulation rewards, self-determine the (…)

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Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus

Faure Philippe — 2023-06-19T09:46:56Z

Elife 2023
Sarah Mondoloni, Claire Nguyen, Eléonore Vicq, Maria Ciscato, Joachim Jehl, Romain Durand-de Cuttoli, Nicolas Torquet, Stefania Tolu, Stéphanie Pons, Uwe Maskos, Fabio Marti, Philippe Faure , Alexandre Mourot
Abstract
Nicotine intake is likely to result from a balance between the rewarding and aversive properties of the drug, yet the individual differences in neural activity that control aversion to nicotine and their adaptation during the addiction process remain largely (…)

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Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state

Nicolas Debray — 2024-10-25T14:50:19Z

Nature Communications 2024 Reynolds LM, Gulmez A, Fayad SL, Campos RC, Rigoni D, Nguyen C, Le Borgne T, Topilko T, Rajot D, Franco C, Marti F, Heck N, Mourot A, Renier N, Barik J, and Faure Ph.
Abstract
How nicotine acts on developing neurocircuitry in adolescence to promote later addiction vulnerability remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient nicotine exposure in early adolescent (PND 21-28) male mice was (…)

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Threat-dependent scaling of prelimbic dynamics to enhance fear representation

Nicolas Debray — 2025-02-06T11:05:10Z

Neuron 2024
Casanova J.P., Pouget C., Treiber N., Agarwal I., Brimble M.A., Vetere G.
Abstract
Promptly identifying threatening stimuli is crucial for survival. Freezing is a natural behavior displayed by rodents toward potential or actual threats. Although it is known that the prelimbic cortex (PL) is involved in both risk evaluation and in fear and anxiety-like behavior expression, here we explored whether PL neuronal activity can dynamically represent different internal states of (…)

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Diverting glial glycolytic flux towards neurons : a memory-relevant role of CRH stress hormone signalling

Nicolas Debray — 2025-02-06T11:26:30Z

Nat Commun 2024
Francés, R., Rabah, Y., Preat, T.*, and Plaçais, P.-Y.*
Abstract
An essential role of glial cells is to comply with the large and fluctuating energy needs of neurons. Metabolic adaptation is integral to the acute stress response, suggesting that glial cells could be major, yet overlooked, targets of stress hormones. Here we show that Dh44 neuropeptide, Drosophila homologue of mammalian corticotropin-releasing hormone (CRH), acts as an experience-dependent metabolic (…)

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Dopamine Builds and Reveals Reward-Associated Latent Behavioral Attractors

Nicolas Debray — 2025-02-06T11:31:06Z

Nature Communications 2024 Naudé J, Sarazin MXB, Mondoloni S, Hanesse B, Vicq E, Amegandjin F, Mourot A, Faure P, Delord B.
Abstract
Phasic variations in dopamine levels are interpreted as a teaching signal reinforcing rewarded behaviors. However, behavior also depends on the motivational, neuromodulatory effect of phasic dopamine. In this study, we reveal a neurodynamical principle that unifies these roles in a recurrent network-based decision architecture embodied through an (…)

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Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer's disease model

Nicolas Debray — 2025-02-06T11:35:13Z

Nature Metabolism 2025 Rabah Y, Berwick JP, Sagar N, Pasquer L, Plaçais PY & Preat T
Abstract
Astrocytes help protect neurons from potential damage caused by reactive oxygen species (ROS). While ROS can also exert beneficial effects, it remains unknown how neuronal ROS signalling is activated during memory formation, and whether astrocytes play a role in this process. Here we discover an astrocyte-to-neuron H2O2 signalling cascade in Drosophila that is essential for long-term memory (…)

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